ABSTRACT
100 leprosy patients were studied for audiovestibular involvement. Conductive hearing loss was detected in 6 cases of BT leprosy, all of them having coincidental chronic middle ear infection. Sensori-neural hearing loss was detected in 10 cases, of which 6 had LL, 2 BT and 2 pure neuritic type of disease respectively. All the cases of lepromatous leprosy having sensorineural hearing loss had evidence of ENL reaction. Vestibular involvement was not detected in any of the cases. Evaluation of audiovestibular function was also carried out in 50 fresh cases of leprosy and after 3 months, 6 months and 1 year of multidrug therapy to ascertain any ototoxic side effects of antileprosy drugs. No audiovestibular dysfunction was detected in these patients at any time during follow-up.
Subject(s)
Adult , Audiometry, Pure-Tone , Evaluation Studies as Topic , Female , Hearing Loss, Conductive/complications , Hearing Loss, Sensorineural/physiopathology , Humans , Leprostatic Agents/adverse effects , Leprosy/complications , Leprosy, Borderline/complications , Leprosy, Lepromatous/complications , Leprosy, Tuberculoid/complications , Male , Middle Aged , Nystagmus, Physiologic , Otitis Media, Suppurative/complications , Vestibular Function TestsABSTRACT
Fifty eight cases including 44 paucibacillary and 14 multibacillary leprosy diagnosed at Command Hospital SC Pune were hospitalised for the entire period of multidrug therapy. 76% cases belonged to high endemic states of India. Reactions occurred in 13 cases during treatment, type I in 10 and type II in three. 7 Multibacillary cases experienced reaction. 69% reaction patients developed reaction within two months of starting MDT and all of them were multibacillary. Usually it took 3-6 months for majority (61.5%) of reactions subside completely. In 65.5% paucibacillary patients activity subsided within twelve months, however 70.5% paucibacillary cases took more than six months to exhibit subsidence of activity. In 13 multibacillary cases activity subsided by 18 months though bacteriological negativity was obtained from fourth to twelve months.
Subject(s)
Adult , Clofazimine/therapeutic use , Dapsone/therapeutic use , Drug Resistance, Microbial , Drug Therapy, Combination , Female , Humans , Leprosy/drug therapy , Male , Rifampin/therapeutic useABSTRACT
A case of leprosy with pellagroid features is presented. Diagnosis of leprosy was confirmed by bacteriological and histopathological examination. A therapeutic trial with nicotinic acid did not result in any improvement. Occurrence of scaling in leprosy is discussed.
Subject(s)
Adult , Diagnosis, Differential , Humans , Leprosy/pathology , Male , Pellagra , Skin/pathologyABSTRACT
Thermal sensory perception quantitatively was studied in follow up of 10 lesions (4 TT, 3 BT and 1 Indeterminate case) of cases put on poly therapy as per WHO regime, for 6 months. Significant thermal sensory improvements was noticed in 4 lesions after 4 months of therapy. Within 2 months of therapy, 3 cases showed improved perception of heat sensation but 1 showed deterioration. Recovery of sensations did not correspond to other clinical parameters of improvement in all the cases. The utility of quantitative evaluation of thermal sensory perception in follow up of leprosy cases is discussed.
Subject(s)
Hot Temperature , Humans , Leprosy/drug therapy , Sensory Thresholds , ThermosensingABSTRACT
A case of Inoculation Leprosy following tattooing in a soldier is being reported. Escape of infection in one tattoo and occurrence of disease in another when tattooing was done simultaneously, is of interest. Possible mechanism for such occurrence is discussed.